What Is Semaglutide?
Semaglutide is a prescription medication used to manage type 2
diabetes and support weight management in individuals with obesity or
overweight conditions.
It belongs to a class of drugs known as GLP-1 receptor agonists (GLP-1
RAs), which mimic the function of the natural hormone glucagon-like
peptide-1 (GLP-1) to regulate blood sugar levels and appetite. Other
medications in this class include liraglutide and dulaglutide.
Semaglutide is often used as part of a holistic approach, complementing
other treatments such as a healthy diet, regular physical activity, and
lifestyle modifications tailored to individual health needs.
Understanding Digestion and Blood Sugar Regulation
Digestion plays a key role in how the body processes food and regulates blood sugar.
When you eat, carbohydrates break down into glucose, the body's main energy source.
This triggers the pancreas to release insulin, which moves glucose into cells for
energy. At the same time, the pancreas produces glucagon, a hormone that signals the
liver to release stored glucose when blood sugar levels drop.
In type 2
diabetes, this system is impaired, leading to insulin resistance, excess
glucose production, and unstable blood sugar levels.
Digestion also affects appetite and weight, as the rate at which food leaves the
stomach (gastric emptying) influences hunger and nutrient absorption. Faster
digestion can cause blood sugar spikes, while slower digestion helps regulate
appetite and glucose levels.
Semaglutide Mechanism of Action
Semaglutide works by regulating blood sugar levels and body weight through the following mechanisms:
- Stimulates insulin release when blood sugar levels are high, allowing the body to move glucose from the bloodstream into cells, where it is used for energy. This helps prevent sharp spikes in blood sugar.
- Reduces glucagon secretion, which lowers the amount of glucose released by the liver into the bloodstream. This helps maintain stable blood sugar levels and prevents the body from producing excess glucose when it is not needed.
- Activates GLP-1 receptors in the brain, which help regulate appetite by reducing hunger signals and food cravings, leading to a decreased desire to eat.
- Slows down gastric emptying, meaning food stays in the stomach longer before moving into the small intestine. This delays the movement of nutrients into the bloodstream, helping to regulate blood sugar levels, prolong feelings of fullness, and reduce overall calorie intake.
Additionally, semaglutide has also been shown to help reduce the risk of heart attack, stroke, and death in individuals with obesity and existing cardiovascular conditions.
Types of Semaglutide in Singapore
Semaglutide is available in different brands formulations, each designed for specific medical purposes:
| Formulation | Uses |
|---|---|
| Ozempic® | A once-weekly injectable formulation primarily prescribed for type 2 diabetes management. It helps regulate blood sugar levels and may also contribute to weight loss. |
| Wegovy® | A higher-dose injectable form of semaglutide approved specifically for weight management in individuals who are obese (BMI ≥30) or overweight (BMI ≥27) with weight-related conditions. |
| Rybelsus® | The oral tablet form of semaglutide, taken once daily for type 2 diabetes management. It provides an alternative for those who prefer a non-injectable option. |
Potential Semaglutide Side Effects
As with all medications, semaglutide may cause side effects. Some of the most commonly reported include:
- Gastrointestinal issues – Nausea, vomiting, diarrhoea, constipation, bloating, or abdominal discomfort.
- Fatigue – Some individuals report feeling tired or weak.
- Dizziness – A possible side effect, especially when starting treatment.
- Injection site reactions – Redness, swelling, or irritation (for injectable forms).
- Mild increases in heart rate – Some users may experience a slight elevation in resting heart rate.
Most side effects improve as the body adjusts to semaglutide. However, seek medical
attention if you experience persistent nausea, severe abdominal pain, significant
dehydration, or symptoms of pancreatitis or gallbladder issues.
Always consult your doctor for personalised advice on managing side effects.
Who Is Semaglutide Not Suitable for?
Semaglutide may not be recommended for individuals with:
- Type 1 diabetes – Semaglutide enhances insulin secretion in response to food, which is ineffective in type 1 diabetes as the body cannot produce insulin.
- History of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 – Some studies suggest a potential link between GLP-1 RAs and thyroid tumours, although the evidence is not conclusive. Therefore, avoiding these medications may be recommended as a precautionary measure for those with a personal or family history of these conditions.
- Severe gastrointestinal conditions – Semaglutide slows digestion and may worsen symptoms in individuals with underlying gastrointestinal issues.
Where Can I Get Semaglutide in Singapore?
Semaglutide is a prescription-only medication in Singapore and
cannot be purchased over the counter. It must be prescribed by a licensed healthcare
provider after a medical consultation to assess your medical history, potential
benefits, and any precautions.
If you are considering semaglutide for type 2 diabetes management or weight loss, consult a
doctor to determine your suitability and receive a treatment plan tailored
to your health needs. It is also important to regularly follow up to monitor your
response to treatment and adjust the dosage if needed.
Why Choose ATA Medical?
Making a Difference Together
At ATA Medical, we strive to make a meaningful impact on every patient's health. With over 120,000 patients served, we are dedicated to fostering trust and enhancing well-being across our community.
Patients
Health Screening Tests
Corporate Screenings
Our Esteemed Clientele Include
What to Expect
FAST RESULTS
We strive to deliver your results within 7 working days.
MINIMUM WAITING TIME
Our patient-oriented processes ensure your waiting time is kept to a minimum.
Friendly Service
Service is a top priority for us at ATA Medical.
Email Us at camden@atamed.sg
for More Information.
Book Your Health Screening With Us at 88838892.