What Is Tirzepatide?
Tirzepatide is a prescription injectable medication that
may be considered for individuals who require medical support in managing
metabolic health, including those with conditions related to blood sugar regulation or adults with a higher body mass index
(BMI) and related health conditions.
It works by activating two hormone receptors in the body, glucagon-like peptide-1
(GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP), which help regulate blood sugar
levels, appetite, and digestion. Related medications that act on GLP-1
receptors include semaglutide, liraglutide, and dulaglutide.
In Singapore, tirzepatide may be prescribed to eligible individuals
following a medical assessment. It is administered once a week by
subcutaneous injection. The cost typically starts from $400 onwards and may
increase as the dosage is adjusted over time.
Tirzepatide Mechanism of Action: How Does It Work?
Tirzepatide works by stimulating the GLP-1 and GIP receptors in the body, leading to several effects such as:
- Appetite regulation, which helps reduce hunger and food intake.
- Slower gastric emptying, which means food stays in the stomach longer and helps prevent sharp rises in blood sugar after meals.
- Enhanced insulin secretion, especially through the action of GIP, which improves the body’s ability to lower blood glucose after eating.
- Reduced glucagon levels, which decreases the amount of glucose released by the liver into the bloodstream between meals or during fasting.
Who Is Tirzepatide Suitable For?
Tirzepatide may be an option for adults who need additional medical
support for metabolic health.
It may be considered in situations when:
- The body requires extra support in regulating appetite, digestion, or blood sugar levels, beyond what current measures provide
- Other first-line treatments have caused adverse effects or are not appropriate for the individual
- There is a higher BMI along with associated conditions (such as raised blood pressure or abnormal lipid levels) that indicate further intervention may be beneficial
Tirzepatide is typically prescribed as part of a broader approach that includes dietary adjustments and regular physical activity. A medical evaluation is required to confirm whether it is appropriate for each individual.
What Are the Benefits of Tirzepatide?
Tirzepatide offers several practical benefits that may support long-term treatment adherence:
- Once-weekly dosing, which may be easier to maintain than medications that require daily use.
- User-friendly injection pens, designed for convenient self-administration at home without frequent clinic visits.
- Gradual dose adjustment, allowing your healthcare provider to increase the dose step by step based on your comfort and response.
Potential Tirzepatide Side Effects
As with all medications, tirzepatide may cause side effects. Most are mild to
moderate and often improve as the body adjusts to treatment.
Common side effects may include:
- Nausea
- Diarrhoea
- Vomiting
- Constipation
- Reduced appetite
- Indigestion
Less common but serious side effects may include:
- Pancreatitis
- Severe gastrointestinal symptoms
- Hypoglycaemia, particularly when used with other diabetes medications
- Allergic reactions, such as rash, itching, swelling of the face or throat, difficulty breathing, or dizziness
Seek medical attention promptly if you experience severe abdominal pain, signs of an allergic reaction, or any symptoms that persist or worsen over time.
Disclaimer: This is not a complete list of side effects. Always consult your doctor if you notice anything unusual or if you have concerns during treatment.
Who Should Avoid Tirzepatide?
Tirzepatide is not suitable for everyone. It is generally avoided in individuals with:
- Severe gastrointestinal conditions, such as gastroparesis, because tirzepatide slows stomach emptying and may worsen digestive symptoms.
- A history of pancreatitis, as tirzepatide may increase the risk of recurrence.
- A personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2), due to potential thyroid tumour risks.
- Type 1 diabetes, as tirzepatide is not approved for use in individuals with this condition.
Your doctor will review your medical history and overall health to determine whether tirzepatide is appropriate for your condition.
Is Tirzepatide Available in Singapore?
Tirzepatide is a prescription-only medication in Singapore. It is
not available over the counter and must be prescribed by a licensed healthcare
provider after a medical consultation.
A consultation
is necessary to assess your medical history, current health status, and treatment
goals. This helps determine whether tirzepatide is a suitable option for you.
Ongoing follow-up allows your response to be monitored, your dosage adjusted as
needed, and the treatment to be used responsibly under medical supervision.
Tirzepatide Singapore Price
| Treatment | Price |
|---|---|
| Tirzepatide | From $479.60 (depending on dosage and clinic) |
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