PCSK9 Inhibitors

Transparent Pricing

Same-Day Appointment

MOH-Registered

Near MRT Stations

Lower LDL cholesterol that a statin has not brought to target, with PCSK9 inhibitor injections from $123

• Doctor consultation to check your cholesterol and whether a PCSK9 inhibitor suits you
• Injections once or twice a month, or just twice a year, depending on the medicine
• Your medicine ordered in for you, usually ready within 2 to 3 working days
• Cholesterol and Lp(a) tests to check your progress after you start

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Located in Tanjong Pagar, Orchard, Jurong & Novena

Medically Reviewed By: Dr Leonard Leng – MBBS, MMed (FM), GDOM, DWD
Last updated: Sep 24, 2026

PCSK9 inhibitors are prescription medicines that lower low-density lipoprotein (LDL) cholesterol, the "bad" cholesterol that builds up in your arteries. They are mainly used when a statin has not lowered LDL cholesterol enough, and most are given as an injection under the skin.

PCSK9, short for proprotein convertase subtilisin/kexin type 9, is a protein made in your liver that affects how much LDL cholesterol your body removes from your blood. People born with a less active form of PCSK9 have lower cholesterol and typically fewer heart problems throughout life, which led to the development of medicines that block it.

PCSK9 inhibitors block the PCSK9 protein, so your liver can remove more LDL cholesterol from your blood.

Your liver cells have LDL receptors on their surface, which catch LDL cholesterol from your blood and take it into the liver to be broken down. PCSK9 destroys these receptors, so less LDL cholesterol is removed. Blocking PCSK9 leaves more receptors in place, and your LDL cholesterol falls.

PCSK9 inhibitors taken with a statin can lower LDL cholesterol by a further 50 to 60 per cent. They also partly lower lipoprotein (a), a genetically inherited cholesterol-carrying particle linked to heart disease.

Four PCSK9 inhibitors are typically used for lowering LDL cholesterol, and they differ mainly in how they are taken and how often:

Statins are usually the first-line treatment for high LDL cholesterol, and ezetimibe, a tablet that reduces how much cholesterol your gut absorbs, is usually prescribed alongside the statin if levels stay high.

PCSK9 inhibitors may be considered when both together are not enough, or for people who cannot take a statin. For people at very high risk, international guidelines recommend keeping LDL cholesterol below 1.4 mmol/L.

They are most often considered for people with:

• Heart disease or a previous stroke – People who have had a heart attack, stroke or narrowed arteries need a very low LDL cholesterol level, as LDL cholesterol builds the fatty deposits that caused the first event. A statin alone often cannot lower it enough.
• Genetically inherited high cholesterol (familial hypercholesterolaemia) – A faulty gene passed down in families means the liver removes less LDL cholesterol, so levels are high from birth. It affects roughly 1 in 300 people, and most do not know they have it.
• Statin side effects – People who cannot take a statin, or only a low dose, because of side effects such as muscle pain need another way to lower their LDL cholesterol.

PCSK9 inhibitors are usually prescribed alongside statins rather than in place of them, as statins remain the first-line treatment and are widely used for preventing heart attacks and strokes.

PCSK9 inhibitors are generally well tolerated, and the most common side effect is redness or pain where the injection is given.

Potential side effects include:

• Injection site reactions – Redness, pain, swelling or bruising can appear where the needle went in. These are usually mild and clear within a few days.
• Cold-like symptoms – A runny nose or sore throat was reported slightly more often than in people given a dummy injection.
• Back or muscle pain – This has been reported, although muscle pain is less common than with statins.
• Allergic reactions – A rash or itching is rare. Seek medical help straight away if your face swells or you have difficulty breathing.

Studies that followed people for several years found no rise in diabetes, memory problems or other serious side effects. PCSK9 inhibitors are generally not used during pregnancy or breastfeeding, as their safety in pregnancy is still being reviewed.

At ATA Medical, PCSK9 inhibitor treatment starts with a consultation, followed by a return visit for the injection once your medicine arrives.

Our doctors review your cholesterol results and discuss whether a PCSK9 inhibitor suits you. If you have not had a recent cholesterol test, blood is taken at this visit and your results are ready in 3 to 5 days.

If a PCSK9 inhibitor is assessed to be suitable and you decide to go ahead, prepayment is required before the medicine is ordered, and it is usually delivered to the clinic within 2 to 3 working days. You then return to the clinic for the injection.

"For people whose LDL cholesterol stays high on a statin, PCSK9 inhibitors offer another way to lower it. Every reduction in LDL cholesterol lowers your risk of a future heart attack or stroke."
— Dr Leonard Leng

"For people whose LDL cholesterol stays high on a statin, PCSK9 inhibitors offer another way to lower it. Every reduction in LDL cholesterol lowers your risk of a future heart attack or stroke."

— Dr Leonard Leng

At ATA Medical, we offer PCSK9 inhibitor injections that are administered fortnightly to monthly or every 6 months depending on the medicine, with consultation and results review.

Our prices are as follows:

• Tanjong Pagar Clinic
• Orchard Clinic
• Jurong Clinic
• Novena Clinic